MLX-interacting protein Recombinant Protein | MLXIP recombinant protein

Recombinant Human MLX-interacting protein (MLXIP), partial

Cat. Num. AAA1470625

• Gene Names: MLXIP; MIR; MONDOA; bHLHe36
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: MLX-interacting protein; Recombinant Human MLX-interacting protein (MLXIP); partial; Class E basic helix-loop-helix protein 36; bHLHe36; Transcriptional activator MondoA; MLXIP recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-217aa; Full Length of Isoform 5
• Sequence: MDEQGCEHTSRTEDPFIQPTDFGPSEPPLSVPPPISPVLPLVPPPATALNPPAPPTFHQPQKFAGVNKAPSVITHTASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLALSPVTRPPQPRLTFVHPKPVSLTGGRPKQPHKIVPAPKPEPVSLVLKNARIAPGEPGGETQCGAPPDPEGCFPIPKAFKLVTTTTTLVCTCMRTHIHLNETKVS
• Sequence Length: 919

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for MLXIP recombinant protein

Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Product Categories/Family for MLXIP recombinant protein

Transcription

References

MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network.Billin A.N., Eilers A.L., Coulter K.L., Logan J.S., Ayer D.E.Mol. Cell. Biol. 20:8845-8854(2000) Mir, a new bHLHZip protein interacting with Mlx.Merla G., Cairo S., Reymond A.Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.DNA Res. 5:355-364(1998) A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.Eilers A.L., Sundwall E., Lin M., Sullivan A.A., Ayer D.E.Mol. Cell. Biol. 22:8514-8526(2002) MondoA-Mlx heterodimers are candidate sensors of cellular energy status mitochondrial localization and direct regulation of glycolysis.Sans C.L., Satterwhite D.J., Stoltzman C.A., Breen K.T., Ayer D.E.Mol. Cell. Biol. 26:4863-4871(2006) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012)

NCBI and Uniprot Product Information

• NCBI GI #: 111955326
• NCBI GeneID: 22877
• NCBI Accession #: NP_055753.3
• NCBI GenBank Nucleotide #: NM_014938.5
• UniProt Accession #: Q9HAP2; O94945; Q7LC47; Q8IXP1; Q8TAH9; Q8WVQ0; Q8WYA5; A7MBN0
• Molecular Weight: 38.8 kDa
• NCBI Official Full Name: MLX-interacting protein
• NCBI Official Synonym Full Names: MLX interacting protein
• NCBI Official Symbol: MLXIP
• NCBI Official Synonym Symbols: MIR; MONDOA; bHLHe36
• NCBI Protein Information: MLX-interacting protein
• UniProt Protein Name: MLX-interacting protein
• Protein Family: MLX-interacting protein
• UniProt Gene Name: MLXIP
• UniProt Synonym Gene Names: bHLHe36
• UniProt Entry Name: MLXIP_HUMAN

NCBI Description

This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]

Uniprot Description

MLXIP: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: mitochondrial outer membrane; nucleus

Molecular Function: DNA binding; protein dimerization activity; transcription factor activity

Biological Process: nucleocytoplasmic transport; transcription, DNA-dependent