Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) ; translocated to, 11 ELISA Kit | MLLT11 elisa kit
Human Protein AF1q, MLLT11 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]
Uniprot Description
MLLT11: a protein that is highly expressed in thymus and leukemic cell lines. A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with MLL.
Protein type: Oncoprotein
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: intracellular
Biological Process: positive regulation of mitochondrial depolarization; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent
Disease: Juvenile Myelomonocytic Leukemia
Research Articles on MLLT11
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Product Notes
The Human MLLT11 mllt11 (Catalog #AAA9326430) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326430 ELISA Kit recognizes Human MLLT11. It is sometimes possible for the material contained within the vial of "myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) ; translocated to, 11, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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