Rat MAP kinase interacting serine/threonine kinase 2 ELISA Kit | MKNK2 elisa kit
Rat MAP kinase-interacting serine/threonine-protein kinase 2, MKNK2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As2O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Magnesium
Enzyme regulation: Inhibited by CGP57380 and staurosporine
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Product Notes
The Rat MKNK2 mknk2 (Catalog #AAA9330199) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330199 ELISA Kit recognizes Rat MKNK2. It is sometimes possible for the material contained within the vial of "MAP kinase interacting serine/threonine kinase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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