Myo-Inositol Oxygenase Recombinant Protein | MIOX recombinant protein
Recombinant Human Myo-Inositol Oxygenase
Gene Names
MIOX; ALDRL6
Purity
Purity as determined by densitometric image analysis is greater than 95%.
Synonyms
Myo-Inositol Oxygenase; Recombinant Human Myo-Inositol Oxygenase; MIOX Human; Myo-Inositol Oxygenase Human Recombinant; Kidney-Specific Protein 32; Aldehyde Reductase (Aldose Reductase) Like 6; Renal-Specific Oxidoreductase; Aldehyde Reductase-Like 6; MI Oxygenase; EC 1.13.99.1; ALDRL6; Inositol Oxygenase; KSP32; RSOR; MIOX; MIOX recombinant protein
Host
E Coli
Purity/Purification
Purity as determined by densitometric image analysis is greater than 95%.
Form/Format
MIOX was filtered (0.4 um) and lyophilized in 20mM Tris buffer, 50mM NaCl and 5% (w/v) trehalose, pH 7.5.
Filtered White lyophilized (freeze-dried) powder.
Filtered White lyophilized (freeze-dried) powder.
Sequence
MKHHHHHHASMKVTVGPDPS LVYRPDVDPE VAKDKASFRN YTSGPLLDRV FTTYKLMHTH QTVDFVRSKH AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLDRVLM SWGHDEYMYQ VMKFNKFSLP PEAFYMIRFH SFYPWHTGRD YQQLCSQQDL AMLPWVREFN KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW.
Sequence Length
285
Solubility
It is recommended to add 200 ul of deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. MIOX is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Preparation and Storage
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
Related Product Information for MIOX recombinant protein
Introduction: Inositol oxygenase is a non-heme di-iron enzyme which oxidizes myo-inositol to glucuronic acid. In addition, inositol oxygenase oxidizes the less abundant chiro isomer of inositol. MIOX enzyme is a component of the only known pathway for the catabolism of inositol in humans. MIOX is expressed mostly in the kidneys. Reduction of Inositol Oxygenase and accumulation of polyols, such as inositol and xylitol, have been implicated as contributing factors in complications linked with diabetes.
Description: MIOX Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (Met1-Trp285) containing 295 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 34.2kDa.
Description: MIOX Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (Met1-Trp285) containing 295 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 34.2kDa.
Product Categories/Family for MIOX recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24,516 Da
NCBI Official Full Name
inositol oxygenase
NCBI Official Synonym Full Names
myo-inositol oxygenase
NCBI Official Symbol
MIOX
NCBI Official Synonym Symbols
ALDRL6
NCBI Protein Information
inositol oxygenase
UniProt Protein Name
Inositol oxygenase
Protein Family
UniProt Gene Name
MIOX
UniProt Synonym Gene Names
ALDRL6; KSP32; RSOR; MI oxygenase
UniProt Entry Name
MIOX_HUMAN
Uniprot Description
MIOX: Belongs to the myo-inositol oxygenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - inositol phosphate; EC 1.13.99.1; Oxidoreductase
Chromosomal Location of Human Ortholog: 22q13.3
Cellular Component: cytoplasm; inclusion body
Molecular Function: aldo-keto reductase activity; ferric iron binding; inositol oxygenase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
Biological Process: inositol catabolic process
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Product Notes
The MIOX miox (Catalog #AAA140688) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MKHHHHH HASMKV TVGPDPS LVYRPDVDPE VAKDKASFRN YTSGPLLDRV FTTYKLMHTH QTVDFVRSKH AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLDRVLM SWGHDEYMYQ VMKFNKFSLP PEAFYMIRFH SFYPWHTGRD YQQLCSQQDL AMLPWVREFN KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW.. It is sometimes possible for the material contained within the vial of "Myo-Inositol Oxygenase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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