Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 Recombinant Protein | MINPP1 recombinant protein

Recombinant Human Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 Protein (C-6His)

Cat. Num. AAA2552974

• Gene Names: MINPP1; MIPP; HIPER1; MINPP2
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Multiple Inositol Polyphosphate Phosphatase 1/MINPP1; Recombinant Human Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 Protein (C-6His); Multiple Inositol Polyphosphate Phosphatase 1; 2; 3-Bisphosphoglycerate 3-Phosphatase; 3-BPG Phosphatase; Inositol (1; 3; 4; 5)-Tetrakisphosphate 3-Phosphatase; Ins(1; 5)P(4) 3-Phosphatase; MINPP1; MIPP; MINPP1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM Tris HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
• Sequence Positions: Ser31-Leu487
• Sequence Length: 312

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for MINPP1 recombinant protein

Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2, 3 bisphosphoglycerate (2, 3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). MINPP1 may play a role in bone development (endochondral ossification).

NCBI and Uniprot Product Information

• NCBI GI #: 296010986
• NCBI GeneID: 9562
• NCBI Accession #: NP_001171588.1
• NCBI GenBank Nucleotide #: NM_001178117.1
• UniProt Accession #: Q9UNW1; O95172; O95286; Q59EJ2; Q9UGA3; F5H683
• Molecular Weight: Molecular Mass: 53.1 kDa; Actual Protein Molecular Mass: 56 kDa
• NCBI Official Full Name: multiple inositol polyphosphate phosphatase 1 isoform 2
• NCBI Official Synonym Full Names: multiple inositol-polyphosphate phosphatase 1
• NCBI Official Symbol: MINPP1
• NCBI Official Synonym Symbols: MIPP; HIPER1; MINPP2
• NCBI Protein Information: multiple inositol polyphosphate phosphatase 1
• UniProt Protein Name: Multiple inositol polyphosphate phosphatase 1
• Protein Family: Multiple inositol polyphosphate phosphatase
• UniProt Gene Name: MINPP1
• UniProt Synonym Gene Names: MIPP; 2,3-BPG phosphatase1 PublicationManual assertion based on opinion iniRef.12; Ins(1,3,4,5)P(4) 3-phosphatase

NCBI Description

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

Uniprot Description

Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy ().