Mitochondrial intermembrane space import and assembly protein 40 (mia40) Recombinant Protein | AN6694.2 recombinant protein
Recombinant Emericella nidulans Mitochondrial intermembrane space import and assembly protein 40 (mia40)
NCBI and Uniprot Product Information
Uniprot Description
Function: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS
By similarity.
Cofactor: Copper or zinc
By similarity.
Subunit structure: Monomer
By similarity.
Subcellular location: Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side
By similarity.
Domain: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria
By similarity.
Sequence similarities: Contains 1 CHCH domain.
Sequence caution: The sequence EAA58512.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN6694 has been split into 2 genes: AN6694 and AN11898.
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Product Notes
The AN6694.2 mia40 (Catalog #AAA1225083) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 36-283. The amino acid sequence is listed below: KPRSWKNTFI RVGLASGAVY YYNTSSVFAE TPSLSFRPEA QPKHEDGKSL PTLDSIKPKS REEKKAPAAA ADAAATPAST GANAQSESPL KSAEELEAEA DQQAAFNPET GEINWDCPCL GGMAYGPCGE EFRAAFSCFV YSEEEPKGMD CIDKFKAMQD CFRAHPDVYG AELDDDEEAG AEANAAGVEQ PLAAEVDASV PVEKHEQAKE VRDEVKSAAG EVAESEEVVP KALDVSEQEK TPEQQTEK. It is sometimes possible for the material contained within the vial of "Mitochondrial intermembrane space import and assembly protein 40 (mia40), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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