Growth Hormone Active Protein | mGH active protein

Recombinant Mouse Growth Hormone

Cat. Num. AAA143198

• Gene Names: Gh; Gh1
• Purity: Greater than 95.0% as determined by:; ; (a) Analysis by RP-HPLC. ; (b) Analysis by SDS-PAGE.
• Synonyms: Growth Hormone; Recombinant Mouse Growth Hormone; GH1; GH; GHN; GH-N; hGH-N; Pituitary growth hormone; Growth hormone 1; Somatotropin.; mGH active protein

• Purity/Purification: Greater than 95.0% as determined by:; ; (a) Analysis by RP-HPLC. ; (b) Analysis by SDS-PAGE.
• Form/Format: Mouse Growth Hormone Recombinant contains 50mM Tris-HCl, pH8.0, 150mM NaCl buffer.
• Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Met-Phe-Pro-Ala-Met
• Sequence Length: 216

• Source: E Coli
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Solubility: It is recommended to reconstitute the lyophilized Growth Hormone murine in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: Recombinant Mouse Growth Hormone is fully biologically active when compared to standard Human Growth Hormone which is 3 units/mg.
• Preparation and Storage: Lyophilized Growth Hormone mouse although stable at room temperature for 3 weeks, should be stored desiccated below -18° C. Upon reconstitution GH mouse should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; ; Please prevent freeze-thaw cycles.

Related Product Information for mGH active protein

Description: Growth Hormone Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 191 amino acids and having a molecular mass of 22 kDa. Mouse GH is purified by proprietary chromatographic techniques.

Introduction: GH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.

Product Categories/Family for mGH active protein

Cytokines and Growth Factors; Growth Factors; Growth Hormone

NCBI and Uniprot Product Information

• NCBI GI #: 6679997
• NCBI GeneID: 14599
• NCBI Accession #: NP_032143.1
• NCBI GenBank Nucleotide #: NM_008117.3
• UniProt Accession #: P06880; Q544X1
• NCBI Official Full Name: somatotropin
• NCBI Official Synonym Full Names: growth hormone
• NCBI Official Symbol: Gh
• NCBI Official Synonym Symbols: Gh1
• NCBI Protein Information: somatotropin
• UniProt Protein Name: Somatotropin
• Protein Family: Growth hormone
• UniProt Gene Name: Gh1
• UniProt Synonym Gene Names: Gh
• UniProt Entry Name: SOMA_MOUSE

Uniprot Description

GH: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A); also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH. Defects in GH1 are the cause of Kowarski syndrome (KWKS); also known as pituitary dwarfism VI. Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2). IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Hormone

Cellular Component: extracellular space; mitochondrion; extracellular region; plasma membrane; trans-Golgi network; cytosol; nucleus; secretory granule

Molecular Function: growth hormone receptor binding; metal ion binding; hormone activity

Biological Process: response to food; response to light stimulus; positive regulation of neurogenesis; cellular response to insulin stimulus; neuroblast proliferation; positive regulation of multicellular organism growth; glucose transport; regulation of steroid hormone receptor signaling pathway; signal transduction; alveolus development; positive regulation of growth