Meteorin-Like Recombinant Protein | METRNL recombinant protein

Recombinant Human Meteorin-Like Protein

Cat. Num. AAA141369

• Purity: >95.0% as determined by SDS-PAGE
• Synonyms: Meteorin-Like; Recombinant Human Meteorin-Like Protein; Meteorin-Like Protein Human Recombinant; Meteorin-like protein; Subfatin; METRNL; METRNL Human; METRNL recombinant protein

• Host: E Coli
• Purity/Purification: >95.0% as determined by SDS-PAGE
• Form/Format: Filtered White Lyophilized (Freeze-Dried) Powder; Filtered (0.4 um) and lyophilized from 0.5mg/ml in 50mM acetate buffer, 5% trehalose (w/v) and 1mM DTT, pH 4.
• Sequence: MKHHHHHHAS QYSSDRCSWK GSGLTHEAHR KEVEQVYLRC AAGAVEWMYP TGALIVNLRP NTFSPARHLT VCIRSFTDSS GANIYLEKTG ELRLLVPDGD GRPGRVQCFG LEQGGLFVEA TPQQDIGRRT TGFQYELVRR HRASDLHELS APCRPCSDTE VLLAVCTSDF AVRGSIQQVT HEPERQDSAI HLRVSRLYRQ KSRVFEPVPE GDGHWQGRVR TLLECGVRPG HGDFLFTGHM HFGEARLGCA PRFKDFQRMY RDAQERGLNP CEVGTD
• Sequence Length: 311

• Solubility: It is recommended to add 0.1M acetate buffer, pH 4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely.
• Preparation and Storage: Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.; Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Related Product Information for METRNL recombinant protein

Introduction: METRNL or Meteorin-like protein is a hormone, released after physical activity (in skeletal muscle) or exposure to cold (in adipose tissue), that induces energy rate. METRNL stimulates energy rate correlate with white fat browning and raise glucose tolerance. The protein stimulates different types of immune cells to enter the fat tissue and start their prothermogenic actions.

Description: METRNL Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 46-311) containing 276 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 31.2kDa (calculated).

Product Categories/Family for METRNL recombinant protein

Recombinant & Natural Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 52345387
• NCBI GeneID: 284207
• NCBI Accession #: NP_001004431.1
• NCBI GenBank Nucleotide #: NM_001004431.3
• UniProt Accession #: Q641Q3
• NCBI Official Full Name: meteorin-like protein isoform 1
• NCBI Official Synonym Full Names: meteorin like, glial cell differentiation regulator
• NCBI Official Symbol: METRNL
• NCBI Protein Information: meteorin-like protein
• UniProt Protein Name: Meteorin-like protein
• Protein Family: Meteorin-like protein
• UniProt Gene Name: METRNL

Uniprot Description

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures ().