Rabbit anti-Human TAL1 Polyclonal Antibody | anti-TAL1 antibody

TAL1 (T90) (T-cell Acute Lymphocytic Leukemia Protein 1, TAL-1, Stem Cell Protein, T-cell Leukemia/Lymphoma Protein 5, Class A Basic Helix-loop-helix Protein 17, bHLHa17, SCL, TCL5) (APC)

Cat. Num. AAA6502064

• Gene Names: TAL1; SCL; TCL5; tal-1; bHLHa17
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Immunoaffinity chromatography.
• Synonyms: TAL1; Polyclonal Antibody; TAL1 (T90) (T-cell Acute Lymphocytic Leukemia Protein 1; TAL-1; Stem Cell Protein; T-cell Leukemia/Lymphoma Protein 5; Class A Basic Helix-loop-helix Protein 17; bHLHa17; SCL; TCL5) (APC); anti-TAL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TAL1.
• Purity/Purification: Purified by Immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-TAL1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:50-1:100; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to amino acid residues surrounding T90 of human TAL1 (KLH).
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-TAL1 Antibody (T90) in Jurkat cell line lysates (35ug/lane). TAL1 (arrow) was detected using the purified Pab.)

Product Categories/Family for anti-TAL1 antibody

Antibodies; Proteins

References

1. Kassouf, M.T., Blood 112(4), 1056-1067 (2008). 2. Terme, J.M., J. Virol. 82(16), 7913-7922 (2008). 3. Brunet de la Grange, P., Stem Cells 26(6), 1658-1662 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 4507363
• NCBI GeneID: 6886
• NCBI Accession #: NP_003180
• NCBI GenBank Nucleotide #: NM_003189
• UniProt Accession #: P17542; D3DQ24
• Molecular Weight: 16,548 Da
• NCBI Official Full Name: T-cell acute lymphocytic leukemia protein 1 isoform 1
• NCBI Official Synonym Full Names: T-cell acute lymphocytic leukemia 1
• NCBI Official Symbol: TAL1
• NCBI Official Synonym Symbols: SCL; TCL5; tal-1; bHLHa17
• NCBI Protein Information: T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; class A basic helix-loop-helix protein 17; stem cell protein; tal-1 product
• UniProt Protein Name: T-cell acute lymphocytic leukemia protein 1
• Protein Family: Transaldolase
• UniProt Gene Name: TAL1
• UniProt Synonym Gene Names: BHLHA17; SCL; TCL5; TAL-1; bHLHa17
• UniProt Entry Name: TAL1_HUMAN

Uniprot Description

TAL1: a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: transcription factor complex; histone deacetylase complex; nuclear chromatin; nucleus

Molecular Function: protein binding; enzyme binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; erythrocyte maturation; cell fate commitment; positive regulation of chromatin assembly or disassembly; embryonic hemopoiesis; megakaryocyte differentiation; positive regulation of transcription, DNA-dependent; positive regulation of erythrocyte differentiation; astrocyte fate commitment; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of protein complex assembly; positive regulation of cell division; erythrocyte differentiation; spinal cord association neuron differentiation; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; platelet formation; basophil differentiation

Disease: Leukemia, Acute Lymphoblastic