Methionine Aminopeptidase 1D/MetAP1D/MAP1D Recombinant Protein | MetAP1D/MAP1D recombinant protein

Recombinant Human Methionine Aminopeptidase 1D/MetAP1D/MAP1D Protein (N, C-6His)

Cat. Num. AAA2552956

• Gene Names: METAP1D; MAP1D; MAP 1D; Metap1l; MetAP 1D
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: Methionine Aminopeptidase 1D/MetAP1D/MAP1D; Recombinant Human Methionine Aminopeptidase 1D/MetAP1D/MAP1D Protein (N; C-6His); Methionine Aminopeptidase 1D Mitochondrial; Methionyl Aminopeptidase Type 1D Mitochondrial; METAP1D; MAP1D; MetAP1D/MAP1D recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 50mM Tris, 100mM NaCl, pH 8.0.
• Sequence Positions: Arg44-Ala335
• Sequence Length: 217

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N, C-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for MetAP1D/MAP1D recombinant protein

Methionine Aminopeptidase 1D (METAP1D) is a mitochondrion protein that belongs to the peptidase M24A family. METAP1D is overexpressed at the protein level in colon cancer cell lines and colon tumors as compared to normal tissues. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins. METAP1D is also active with zinc, manganese or divalent ions. It may also play an important role in colon tumorigenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 1016470462
• NCBI GeneID: 254042
• NCBI Accession #: NP_001309207.1
• NCBI GenBank Nucleotide #: NM_001322278.1
• UniProt Accession #: Q6UB28; Q1WNX3
• Molecular Weight: Molecular Mass: 35.4 kDa; Actual Protein Molecular Mass: 32 kDa
• NCBI Official Full Name: methionine aminopeptidase 1D, mitochondrial isoform 2
• NCBI Official Synonym Full Names: methionyl aminopeptidase type 1D, mitochondrial
• NCBI Official Symbol: METAP1D
• NCBI Official Synonym Symbols: MAP1D; MAP 1D; Metap1l; MetAP 1D
• NCBI Protein Information: methionine aminopeptidase 1D, mitochondrial
• UniProt Protein Name: Methionine aminopeptidase 1D, mitochondrial
• UniProt Gene Name: METAP1D
• UniProt Synonym Gene Names: MAP1D; MAP 1D

NCBI Description

The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]

Uniprot Description

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (). May play a role in colon tumorigenesis.