Hepatocyte growth factor receptor (Met) Recombinant Protein | Met recombinant protein

Recombinant Mouse Hepatocyte growth factor receptor (Met) , partial

• Gene Names: Met; HGF; HGFR; Par4; c-Met; AI838057
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Hepatocyte growth factor receptor (Met); Recombinant Mouse Hepatocyte growth factor receptor (Met); partial; Met recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,379

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Met recombinant protein

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 125485
• NCBI GeneID: 17295
• UniProt Accession #: P16056; Q62125
• Molecular Weight: 153,549 Da
• NCBI Official Full Name: Hepatocyte growth factor receptor
• NCBI Official Synonym Full Names: met proto-oncogene
• NCBI Official Symbol: Met
• NCBI Official Synonym Symbols: HGF; HGFR; Par4; c-Met; AI838057
• NCBI Protein Information: hepatocyte growth factor receptor
• UniProt Protein Name: Hepatocyte growth factor receptor
• Protein Family: Hepatocyte growth factor receptor
• UniProt Gene Name: Met
• UniProt Synonym Gene Names: HGF receptor; SF receptor

Uniprot Description

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (). May regulate cortical bone osteogenesis (PubMed:26637977).