Typical Testing Data/Standard Curve (for reference only)
Rat Hepatocyte growth factor receptor ELISA Kit | Met elisa kit
Rat Hepatocyte growth factor receptor ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
hepatocyte growth factor receptor; functions as a heterodimeric tyrosine kinase [RGD, Feb 2006]
Uniprot Description
Met: a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported.
Protein type: Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; Oncoprotein; Membrane protein, integral; TK group; Met family
Cellular Component: basal plasma membrane; cell soma; cell surface; cytoplasm; dendrite; excitatory synapse; extracellular space; integral to membrane; membrane; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane
Molecular Function: ATP binding; beta-catenin binding; hepatocyte growth factor receptor activity; phosphoinositide 3-kinase binding; phospholipase binding; protein complex binding; protein heterodimerization activity; protein kinase activity; protein phosphatase binding; protein-tyrosine kinase activity
Biological Process: activation of MAPK activity; adult behavior; brain development; branching morphogenesis of a tube; cardiac muscle cell development; cardiac muscle contraction; cell aging; central nervous system neuron differentiation; endothelial cell morphogenesis; glucose homeostasis; hepatocyte growth factor receptor signaling pathway; lactation; liver development; male gonad development; muscle cell migration; muscle development; myoblast proliferation; myotube differentiation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; oligodendrocyte development; pancreas development; peptidyl-tyrosine phosphorylation; placenta development; positive chemotaxis; positive regulation of dendrite morphogenesis; positive regulation of DNA replication; positive regulation of mitosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; regulation of excitatory postsynaptic membrane potential; regulation of interleukin-6 production; regulation of synaptic transmission; response to acidity; response to drug; response to organic cyclic substance; response to peptide hormone stimulus; response to wounding; skeletal muscle development; sperm motility; synaptic transmission
Research Articles on Met
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Product Notes
The Rat Met met (Catalog #AAA2884279) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2884279 ELISA Kit recognizes Rat Met. It is sometimes possible for the material contained within the vial of "Hepatocyte growth factor receptor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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