Tyrosine-protein kinase Mer (Mertk) Recombinant Protein | Mertk recombinant protein

Recombinant Rat Tyrosine-protein kinase Mer (Mertk), partial

Cat. Num. AAA950302

• Gene Names: Mertk; rdy
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Tyrosine-protein kinase Mer (Mertk); Recombinant Rat Tyrosine-protein kinase Mer (Mertk); partial; Mertk recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 19-497. Partial
• Sequence: GGTAEKEEEIKPDQPFSGPLPGSLPADHRPFFAPHSSGDQLSPSQTGRSHPAHTATPQMTSAASNLLPPVAFKNTIGRIVLSEHKSVKFNCSINIPNVYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSITSVQRSDNGSYICKMKVNDREVVSDPIYVEVQGLPYFTKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNENPERSPSVLTVAGLTETAVFSCEAHNDKGLTVSKGVQINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADQLSNGSVMVFNTSASPHLYEVQQLQALANYSVTVSCRNEIGWSAVSPWILASTTEGAPAVAPLNITVFLNESSNNLEIRWTKPPIKRQDGELVGYRISHVWESAGTSKELSEEVSQNGSWAQVPVQMHNATCTVRIAVITKGGIGPFSEPVDVAIPEHSRVDYAPSSTPAPGNTESM

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Mertk recombinant protein

This gene is a member of the MER
AXL
TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

NCBI and Uniprot Product Information

• NCBI GI #: 12738847
• NCBI GeneID: 65037
• NCBI Accession #: NP_075232.1
• NCBI GenBank Nucleotide #: NM_022943.1
• UniProt Accession #: P57097
• Molecular Weight: 55.5
• NCBI Official Full Name: tyrosine-protein kinase Mer
• NCBI Official Synonym Full Names: MER proto-oncogene, tyrosine kinase
• NCBI Official Symbol: Mertk
• NCBI Official Synonym Symbols: rdy
• NCBI Protein Information: tyrosine-protein kinase Mer
• UniProt Protein Name: Tyrosine-protein kinase Mer
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: Mertk
• UniProt Synonym Gene Names: Mer

NCBI Description

receptor tyrosine kinase; involved in the phagocytoses of the shed outer segments by retinal pigment epithelial (RPE) cells [RGD, Feb 2006]

Uniprot Description

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 ().