Human mediator complex subunit 1 ELISA Kit | MED1 elisa kit

Human Mediator of RNA polymerase II transcription subunit 1, MED1 ELISA Kit

Cat. Num. AAA9322823

• Gene Names: MED1; PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220
• Reactivity: Human
• Synonyms: mediator complex subunit 1; Human Mediator of RNA polymerase II transcription subunit 1; MED1 ELISA Kit; Human Mediator of RNA polymerase II transcription subunit 1 (MED1) ELISA kit; CRSP1; CRSP200; DRIP205; DRIP230; MGC71488; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2; PPAR binding protein; PPARG binding protein; thyroid hormone receptor-associated protein complex component TRAP; MED1 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 28559039
• NCBI GeneID: 5469
• NCBI Accession #: NP_004765.2
• NCBI GenBank Nucleotide #: NM_004774.3
• UniProt Accession #: Q15648; O43810; O75447; Q6P9H7; Q6PK58; Q9HD39; A2RRQ6
• Molecular Weight: 168,478 Da
• NCBI Official Full Name: mediator of RNA polymerase II transcription subunit 1
• NCBI Official Synonym Full Names: mediator complex subunit 1
• NCBI Official Symbol: MED1
• NCBI Official Synonym Symbols: PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220
• NCBI Protein Information: mediator of RNA polymerase II transcription subunit 1; ARC205; TRIP-2; PPAR binding protein; PPAR-binding protein; PPARG binding protein; TR-interacting protein 2; p53 regulatory protein RB18A; thyroid receptor interacting protein 2; thyroid receptor-interacting protein 2; vitamin D receptor-interacting protein 230 kD; activator-recruited cofactor 205 kDa component; peroxisome proliferator-activated receptor-binding protein; vitamin D receptor-interacting protein complex component DRIP205; thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220
• UniProt Protein Name: Mediator of RNA polymerase II transcription subunit 1
• Protein Family: Mediator of RNA polymerase II transcription
• UniProt Gene Name: MED1
• UniProt Synonym Gene Names: ARC205; CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2; ARC205; PBP; PPAR-binding protein; Trap220; TR-interacting protein 2; TRIP-2
• UniProt Entry Name: MED1_HUMAN

NCBI Description

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

Uniprot Description

MED1: a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. Also is a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. May regulates p53-dependent apoptosis. Is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. Two splice-variant isoforms have been described.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: nucleoplasm; membrane; nucleolus; Srb-mediator complex; nucleus; chromatin

Molecular Function: ligand-dependent nuclear receptor binding; peroxisome proliferator activated receptor binding; chromatin DNA binding; retinoic acid receptor binding; transcription coactivator activity; receptor activity; transcription factor binding; thyroid hormone receptor coactivator activity; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; LBD domain binding; transcription cofactor activity; estrogen receptor binding; chromatin binding; thyroid hormone receptor binding; nuclear hormone receptor binding

Biological Process: fat cell differentiation; lens development in camera-type eye; lactation; embryonic placenta development; erythrocyte development; regulation of cell cycle; positive regulation of transcription, DNA-dependent; positive regulation of estrogen receptor signaling pathway; cell morphogenesis; positive regulation of mammary gland epithelial cell proliferation; enucleate erythrocyte development; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; androgen biosynthetic process; embryonic hindlimb morphogenesis; angiogenesis; positive regulation of keratinocyte differentiation; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; organ regeneration; regulation of transcription from RNA polymerase I promoter; positive regulation of protein import into nucleus, translocation; monocyte differentiation; embryonic hemopoiesis; thyroid hormone generation; liver development; mRNA transcription from RNA polymerase II promoter; keratinocyte differentiation; negative regulation of neuron differentiation; androgen receptor signaling pathway; embryonic heart tube development; positive regulation of transcription from RNA polymerase II promoter; gene expression; brain development; negative regulation of apoptosis