MDS1 And EVI1 Complex Locus Recombinant Protein | MECOM recombinant protein
Recombinant Human MDS1 And EVI1 Complex Locus
Sterile Filtered clear solution.
Introduction: MDS1 is a transcriptional regulator and oncoprotein which takes part in hematopoiesis, development, cell differentiation, apoptosis and proliferation. MDS1 is able to interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. Overexpression, as a result of translocation with the AML1 gene, is known to cause leukemia. A number of transcript variants encoding several different isoforms were found.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Description
EVI1: a zinc finger transcriptional regulator that binds to DNA sequences in the promoter region of target genes and positively or negatively regulates their expression. An oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Originally identified as a common site of viral integration in murine myeloid leukemia. Involved in human myeloid disorders through chromosome translocation and inversion and is also implicated in solid tumor formation. At least six isoforms of the human protein are formed due to alternative usage of 5'-ends, alternative splicing, and intergenic splicing which results in the formation of a fusion protein with MDS1, which can be expressed in normal tissues.
Protein type: Transcription, coactivator/corepressor; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; histone deacetylase complex; cytoplasm; nuclear speck; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; metal ion binding; transcription factor activity
Biological Process: embryonic forelimb morphogenesis; negative regulation of JNK cascade; pericardium development; transcription, DNA-dependent; regulation of cell cycle; apoptosis; in utero embryonic development; positive regulation of transcription, DNA-dependent; neutrophil homeostasis; embryonic hindlimb morphogenesis; regulation of cell proliferation; post-embryonic development; response to bacterium; regulation of transcription, DNA-dependent; forebrain development; negative regulation of programmed cell death; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; inflammatory response; negative regulation of transcription, DNA-dependent
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Product Notes
The MECOM mecom (Catalog #AAA145557) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MGSMRS KGRA RKLATNNECV YGNYPEIPLE EMPDADGVAS TPSLNIQEPC SPATSSEAFT PKEGSPYKAP IYIPDDIPIP AEFELRESNM PGAGLGIWTK RKIEVGEKFG PYVGEQRSNL KDPSYGWEVH LPRSRRVSVH SWLYLGKRSS DVGIAFSQAD VYMPGLQCAF LS. It is sometimes possible for the material contained within the vial of "MDS1 And EVI1 Complex Locus, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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