CJ119 Blocking Peptide | MCMBP blocking peptide

CJ119 Antibody (N-term) Blocking Peptide

• Gene Names: MCMBP; MCM-BP; C10orf119
• Synonyms: CJ119; CJ119 Antibody (N-term) Blocking Peptide; Mini-chromosome maintenance complex-binding protein; MCM-BP; MCM-binding protein; MCMBP; C10orf119; MCMBP blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 642

• Cellular Location: Nucleus. Note: Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MCMBP blocking peptide

Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

NCBI and Uniprot Product Information

• NCBI GI #: 71153001
• NCBI GeneID: 79892
• UniProt Accession #: Q9BTE3; Q6IA56; Q9BVT9; Q9H916; B3KSP7
• Molecular Weight: 52,652 Da
• NCBI Official Full Name: Mini-chromosome maintenance complex-binding protein
• NCBI Official Synonym Full Names: minichromosome maintenance complex binding protein
• NCBI Official Symbol: MCMBP
• NCBI Official Synonym Symbols: MCM-BP; C10orf119
• NCBI Protein Information: mini-chromosome maintenance complex-binding protein
• UniProt Protein Name: Mini-chromosome maintenance complex-binding protein
• Protein Family: Mini-chromosome maintenance complex-binding protein
• UniProt Gene Name: MCMBP
• UniProt Synonym Gene Names: C10orf119; MCM-BP; MCM-binding protein
• UniProt Entry Name: MCMBP_HUMAN

NCBI Description

This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Description

MCMBP: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. Belongs to the MCMBP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10q26.11

Cellular Component: cytoplasm; MCM complex; nucleoplasm; nucleus; plasma membrane

Molecular Function: chromatin binding; protein binding

Biological Process: DNA-dependent DNA replication; sister chromatid cohesion