Mouse minichromosome maintenance complex component 3 associated protein ELISA Kit | MCM3AP elisa kit

Mouse 80 kDa MCM3-associated protein, MCM3AP ELISA Kit

Cat. Num. AAA9323977

• Gene Names: Mcm3ap; GANP; mKIAA0572
• Reactivity: Mouse
• Synonyms: minichromosome maintenance complex component 3 associated protein; Mouse 80 kDa MCM3-associated protein; MCM3AP ELISA Kit; Mouse 80 kDa MCM3-associated protein (MCM3AP) ELISA kit; FLJ44336; FLJ45306; GANP; KIAA0572; MAP80; MCM3 import protein; MCM3 minichromosome maintenance deficient 3 associated protein; OTTHUMP00000115776; germinal center-associated nuclear protein; minichromo; MCM3AP elisa kit

• Reactivity: Mouse
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples.
• Assay Type: Sandwich (Quantitative)
• Detection Range: 3.12ng/ml-100ng/ml.
• Sensitivity: 1.0ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for MCM3AP elisa kit

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of MCM3AP (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 109627648
• NCBI GeneID: 54387
• NCBI Accession #: NP_062307.2
• NCBI GenBank Nucleotide #: NM_019434.2
• UniProt Accession #: Q9WUU9; Q7TS87
• Molecular Weight: 217,363 Da
• NCBI Official Full Name: germinal-center associated nuclear protein
• NCBI Official Synonym Full Names: minichromosome maintenance deficient 3 (S. cerevisiae) associated protein
• NCBI Official Symbol: Mcm3ap
• NCBI Official Synonym Symbols: GANP; mKIAA0572
• NCBI Protein Information: germinal-center associated nuclear protein; nuclear protein GANP; GC-associated DNA primase; 80 kDa MCM3-associated protein; minichromosome maintenance deficient 3-associated protein
• UniProt Protein Name: Germinal-center associated nuclear protein
• Protein Family: Germinal-center associated nuclear protein
• UniProt Gene Name: Mcm3ap
• UniProt Synonym Gene Names: Ganp; Map80; GANP
• UniProt Entry Name: GANP_MOUSE

Uniprot Description

GANP: is a member of the SAC3 family of nuclear export factors. In combination with ENY2, PCID2 and centrins, forms the TREX-2 complex that links transcription/ processing with nuclear mRNA export. GANP, required to recruit ENY2 to nuclear pore complexes (NPCs), requires both its CID and MCM3AP domains, together with nucleoporin Nup153, for recruitment to NPCs. The MCM3AP domain, corresponding to the carboxy-terminal 721 amino acids of GANP, shows homology with the Gcn5-related N acetyltransferase superfamily. The protein MCM3AP is encoded entirely within the 3¿ region of the GANP gene. MCM3AP transcription begins within intron 16 of GANP immediately upstream of the first MCM3AP exon, where NF-IL6, AP-1, NF-¿B, and p53 consensus transcription factor binding sites are located. In contrast, the GANP promoter region contains consensus transcription factor binding sites for E2F, E-box, BSAP, and PU.1. MCM3AP interacts with MCM3, which it can acetylate weakly in vivo. GANP is required for efficient mRNA nuclear export: GANP depletion results in the nuclear accumulation of poly(A)+RNA. It interacts via its N-terminal FG repeat domain with the mRNA export factor NXF1. GANP plays a role in the immune response: antibodies from mice deficient for GANP have reduced affinities against T-cell dependent antigens and a lower frequency of variable region somatic mutation. GANP expression is markedly decreased in malignant glioma (MG) with a poor prognosis, consistently lower than that observed in anaplastic astrocytomas. Significant decreases in GANP expression are associated with hyperploidy and chromosomal instability

Protein type: Karyopherin; Acetyltransferase

Cellular Component: nuclear membrane; cytoplasm; nuclear pore; nucleus; cytosol

Biological Process: protein transport; mRNA transport; immune system process; transport