Multicilin (MCI) Recombinant Protein | MCI recombinant protein

Recombinant Human Multicilin (MCI)

Cat. Num. AAA1133324

• Gene Names: MCIDAS; MCI; IDAS; MCIN
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Multicilin (MCI); Recombinant Human Multicilin (MCI); MCI recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-385, Full length protein
• Sequence: MQACGGGAAGRRAFDSICPNRMLALPGRALLCKPGKPERKFAPPRKFFPGCTGGSPVSVYEDPPDAEPTALPALTTIDLQDLADCSSLLGSDAPPGGDLAASQNHSHQTEADFNLQDFRDTVDDLISDSSSMMSPTLASGDFPFSPCDISPFGPCLSPPLDPRALQSPPLRPPDVPPPEQYWKEVADQNQRALGDALVENNQLHVTLTQKQEEIASLKERNVQLKELASRTRHLASVLDKLMITQSRDCGAAAEPFLLKAKAKRSLEELVSAAGQDCAEVDAILREISERCDEALQSRDPKRPRLLPEPANTDTRPGNLHGAFRGLRTDCSRSALNLSHSELEEGGSFSTRIRSHSTIRTLAFPQGNAFTIRTANGGYKFRWVPS
• Sequence Length: 385

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 299782571
• NCBI GeneID: 345643
• NCBI Accession #: NP_001177716.1
• NCBI GenBank Nucleotide #: NM_001190787.1
• UniProt Accession #: D6RGH6; C9JGY3; D6R920; F8KGQ8
• Molecular Weight: 41,720 Da
• NCBI Official Full Name: multicilin
• NCBI Official Synonym Full Names: multiciliate differentiation and DNA synthesis associated cell cycle protein
• NCBI Official Symbol: MCIDAS
• NCBI Official Synonym Symbols: MCI; IDAS; MCIN
• NCBI Protein Information: multicilin
• UniProt Protein Name: Multicilin
• UniProt Gene Name: MCIDAS
• UniProt Synonym Gene Names: IDAS; MCI; MCIN; McIdas protein

NCBI Description

This gene encodes a member of the geminin family of proteins. The encoded nuclear protein is required for the generation of multiciliated cells in respiratory epithelium. Mutations in this gene cause a rare mucociliary clearance disorder associated with recurring respiratory infections in human patients, known as reduced generation of multiple motile cilia (RGMC). [provided by RefSeq, Sep 2016]

Uniprot Description

Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211).