Cell surface glycoprotein MUC18 Recombinant Protein | MUC18 recombinant protein

Recombinant Human Cell surface glycoprotein MUC18

Cat. Num. AAA9421894

• Gene Names: MCAM; CD146; MUC18
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Cell surface glycoprotein MUC18; Recombinant Human Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12Melanoma cell adhesion molecule; Melanoma-associated antigen A32Melanoma-associated antigen MUC18S-endo 1 endothelial-associated antigen; CD146; MUC18 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Partial of the Full Length of 24-646aa, 50-646aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for MUC18 recombinant protein

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elents of the vascular syst, thereby enhancing hatogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during bryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

NCBI and Uniprot Product Information

• NCBI GI #: 71274107
• NCBI GeneID: 4162
• NCBI Accession #: NP_006491.2
• NCBI GenBank Nucleotide #: NM_006500.2
• UniProt Accession #: P43121; O95812; Q59E86; Q6PHR3; Q6ZTR2
• Molecular Weight: 70.7kD
• NCBI Official Full Name: cell surface glycoprotein MUC18
• NCBI Official Synonym Full Names: melanoma cell adhesion molecule
• NCBI Official Symbol: MCAM
• NCBI Official Synonym Symbols: CD146; MUC18
• NCBI Protein Information: cell surface glycoprotein MUC18
• UniProt Protein Name: Cell surface glycoprotein MUC18
• Protein Family: Cell surface glycoprotein
• UniProt Gene Name: MCAM
• UniProt Synonym Gene Names: MUC18

Uniprot Description

MCAM: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: external side of plasma membrane; focal adhesion

Biological Process: anatomical structure morphogenesis; angiogenesis; glomerular filtration