Mitogen-activated protein kinase 6 Recombinant Protein | MK06 recombinant protein

Recombinant Human Mitogen-activated protein kinase 6

Cat. Num. AAA9420442

• Gene Names: MAPK6; ERK3; PRKM6; p97MAPK; HsT17250
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Mitogen-activated protein kinase 6; Recombinant Human Mitogen-activated protein kinase 6; Extracellular signal-regulated kinase 3; ERK-3MAP kinase isoform p97; p97-MAPK; MK06 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-721aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for MK06 recombinant protein

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.

NCBI and Uniprot Product Information

• NCBI GI #: 4506091
• NCBI GeneID: 5597
• NCBI Accession #: NP_002739.1
• NCBI GenBank Nucleotide #: NM_002748.3
• UniProt Accession #: Q16659; Q68DH4; Q8IYN8; B2R945; B5BU65
• Molecular Weight: 98.61kD
• NCBI Official Full Name: mitogen-activated protein kinase 6
• NCBI Official Synonym Full Names: mitogen-activated protein kinase 6
• NCBI Official Symbol: MAPK6
• NCBI Official Synonym Symbols: ERK3; PRKM6; p97MAPK; HsT17250
• NCBI Protein Information: mitogen-activated protein kinase 6
• UniProt Protein Name: Mitogen-activated protein kinase 6
• Protein Family: Mitogen-activated protein kinase
• UniProt Gene Name: MAPK6
• UniProt Synonym Gene Names: ERK3; PRKM6; MAP kinase 6; MAPK 6; ERK-3; p97-MAPK

NCBI Description

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

Uniprot Description

ERK3: a protein kinase of the MAPK family. Plays a critical role in the regulation of cell growth and differentiation. Localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.

Protein type: CMGC group; EC 2.7.11.24; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: MAP kinase activity; protein binding; protein serine/threonine kinase activity

Biological Process: protein amino acid phosphorylation; regulation of gene expression; signal transduction