Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) Recombinant Protein | Map4k4 recombinant protein
Recombinant Mouse Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) , partial
Gene Names
Map4k4; HGK; Nik; AU043147; AU045934; AW046177; 9430080K19Rik
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4); Recombinant Mouse Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4); partial; Map4k4 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Length
1,233
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Map4k4 recombinant protein
This protein is a member of the serine
threonine protein kinase family. This kinase has been shown to specifically activate MAPK8
JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7
TAK1, MAP2K4
MKK4, and MAP2K7
MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
threonine protein kinase family. This kinase has been shown to specifically activate MAPK8
JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7
TAK1, MAP2K4
MKK4, and MAP2K7
MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
140,602 Da
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4 isoform 1
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase kinase 4
NCBI Official Symbol
Map4k4
NCBI Official Synonym Symbols
HGK; Nik; AU043147; AU045934; AW046177; 9430080K19Rik
NCBI Protein Information
mitogen-activated protein kinase kinase kinase kinase 4
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase kinase 4
Protein Family
UniProt Gene Name
Map4k4
UniProt Synonym Gene Names
Nik; MEK kinase kinase 4; MEKKK 4
Uniprot Description
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 ().
Research Articles on Map4k4
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Product Notes
The Map4k4 map4k4 (Catalog #AAA967072) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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