SDS-PAGE
Mitogen-activated protein kinase kinase kinase 1 Recombinant Protein | MAP3K1 recombinant protein
Recombinant Mouse Mitogen-activated protein kinase kinase kinase 1 protein
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]
Uniprot Description
Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. Ref.2
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Magnesium.
Enzyme regulation: Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization.
Subunit structure: Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with STK38. Ref.2 Ref.4 Ref.5 Ref.8
Post-translational modification: Autophosphorylated
By similarity.
Involvement in disease: 46,XY sex reversal 6 (SRXY6) [MIM:613762]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13
Sequence similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Contains 1 protein kinase domain.Contains 1 RING-type zinc finger.Contains 1 SWIM-type zinc finger.
Research Articles on MAP3K1
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Product Notes
The MAP3K1 map3k1 (Catalog #AAA719380) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Mitogen-activated protein kinase kinase kinase 1 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, ELISA (EIA). Researchers should empirically determine the suitability of the MAP3K1 map3k1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: QPYREDAEWL KGQQIGLGAF SSCYQAQDVG TGTLMAVKQV TYVRNTSSEQ EEVVEALREE IRMMGHLNHP NIIRMLGATC EKSNYNLFIE WMAGGSVAHL LSKYGAFKES VVINYTEQLL RGLSYLHENQ IIHRDVKGAN LLIDSTGQRL RIADFGAAAR LASKGTGAGE FQGQLLGTIA FMAPEVLRGQ QYGRSCDVWS VGCAIIEMAC AKPPWNAEKH SNHLALIFKI ASATTAPSIP SHLSPGLRDV ALRCLELQPQ DRPPSRELLK HPVFRTTW. It is sometimes possible for the material contained within the vial of "Mitogen-activated protein kinase kinase kinase 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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