Mouse mitogen-activated protein kinase kinase kinase 1 ELISA Kit | MAP3K1 elisa kit
Mouse Mitogen-activated protein kinase kinase kinase 1, MAP3K1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
MEKK1: a protein kinase of the STE11 family. Phosphorylates and activates MKK4 and -7, which in turn activate JNK1, -2 and -3. Contains 1 RING-type zinc finger. The RING finger domain of MEKK1 exhibits E3 ubiquitin ligase activity toward c-Jun. c-Jun is downregulated in response to osmotic stress via ubiquitination-mediated degradation by the RING finger domain of MEKK1. Overexpressed/overactivated in multiple tumor types. The Mek1/2 inhibitor U0126 blocks export of influenza viral particles and has been suggested as an antiviral treatment. Single mutations at the same point of each gene also associated with cardiofaciocutaneous syndrome, (also linked with Braf and Kras mutations), displaying morphological, cardiac and mental defects. Inhibitors: U0126, CI-1040/PD184352, PD-0325901 (Phase I cancer), ARRY-142886 (Phase 1, cancer).
Protein type: Kinase, protein; EC 2.7.11.25; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Ubiquitin ligase; Ligase; Ubiquitin conjugating system; STE group; STE11 family
Cellular Component: cytoskeleton; membrane; cytoplasm; intracellular; cell junction
Molecular Function: sphingolipid binding; JUN kinase kinase kinase activity; zinc ion binding; mitogen-activated protein kinase kinase binding; metal ion binding; nucleotide binding; ubiquitin-protein ligase activity; JUN kinase kinase activity; protein kinase binding; protein kinase activity; transferase activity; JUN kinase binding; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; transferase activity, transferring phosphorus-containing groups; mitogen-activated protein kinase binding; kinase activity; ATP binding
Biological Process: apoptotic mitochondrial changes; camera-type eye development; wound healing; positive regulation of actin filament polymerization; activation of MAPKK activity; transforming growth factor beta receptor signaling pathway; MAPKKK cascade; JNK cascade; protein ubiquitination; phosphorylation; regulation of cell migration; protein amino acid phosphorylation; activation of JNK activity; activation of JNKK activity
Research Articles on MAP3K1
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Product Notes
The Mouse MAP3K1 map3k1 (Catalog #AAA9340042) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340042 ELISA Kit recognizes Mouse MAP3K1. It is sometimes possible for the material contained within the vial of "mitogen-activated protein kinase kinase kinase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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