Rat mitogen-activated protein kinase kinase 7 ELISA Kit | MAP2K7 elisa kit
Rat Dual specificity mitogen-activated protein kinase kinase 7, MAP2K7 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.1 PublicationManual assertion based on experiment in:Ref.2
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.1 PublicationManual assertion based on experiment in:Ref.2
Cofactor: Magnesium.1 PublicationManual assertion based on experiment in:Ref.2
Enzyme regulation: Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.By similarityManual assertion inferred from sequence similarityUniProtKB:O14733UniProtKB:Q8CE90
Research Articles on MAP2K7
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Product Notes
The Rat MAP2K7 map2k7 (Catalog #AAA9320186) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320186 ELISA Kit recognizes Rat MAP2K7. It is sometimes possible for the material contained within the vial of "mitogen-activated protein kinase kinase 7, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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