Human mitogen-activated protein kinase kinase 5 ELISA Kit | MAP2K5 elisa kit

Human Dual specificity mitogen-activated protein kinase kinase 5, MAP2K5 ELISA Kit

Cat. Num. AAA9342922

• Gene Names: MAP2K5; MEK5; MAPKK5; PRKMK5; HsT17454
• Reactivity: Human
• Synonyms: mitogen-activated protein kinase kinase 5; Human Dual specificity mitogen-activated protein kinase kinase 5; MAP2K5 ELISA Kit; Human Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) ELISA kit; HsT17454; MAPKK5; MEK5; PRKMK5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; dual specificity mitogen-activated protein kinase kinase 5; MAP2K5 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 332164798
• NCBI GeneID: 5607
• NCBI Accession #: NP_001193733.1
• NCBI GenBank Nucleotide #: NM_001206804.1
• UniProt Accession #: Q13163; Q92961; Q92962; B4DE43
• Molecular Weight: 50,112 Da
• NCBI Official Full Name: dual specificity mitogen-activated protein kinase kinase 5 isoform C
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase 5
• NCBI Official Symbol: MAP2K5
• NCBI Official Synonym Symbols: MEK5; MAPKK5; PRKMK5; HsT17454
• NCBI Protein Information: dual specificity mitogen-activated protein kinase kinase 5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b
• UniProt Protein Name: Dual specificity mitogen-activated protein kinase kinase 5
• Protein Family: Mitogen-activated protein kinase kinase
• UniProt Gene Name: MAP2K5
• UniProt Synonym Gene Names: MEK5; MKK5; PRKMK5; MAP kinase kinase 5; MAPKK 5; MEK 5
• UniProt Entry Name: MP2K5_HUMAN

NCBI Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

Uniprot Description

MEK5: a dual specificity protein kinase of the STE7 family. Activates ERK5 and is itself phosphorylated and activated by MEKK3, as well as by atypical protein kinase C isoforms. Involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced isoforms have been described.

Protein type: Protein kinase, STE; Kinase, protein; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: spindle; intracellular; nucleus; cytosol

Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; metal ion binding; ATP binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; negative regulation of heterotypic cell-cell adhesion; nerve growth factor receptor signaling pathway; inhibition of NF-kappaB transcription factor; activation of MAPK activity; heart development; negative regulation of interleukin-8 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; signal transduction; positive regulation of protein metabolic process; positive regulation of cell growth; positive regulation of epithelial cell proliferation