SDS-PAGE
MKK4 / MEK4 / MAP2K4 recombinant protein
Recombinant Mouse MKK4 / MEK4 / MAP2K4 Protein (His & GST tag)
SDS-PAGE
SDS-PAGE
Description: A DNA sequence encoding the mouse MAP2K4 (P47809) (Ala 2-Asp 397) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
NCBI and Uniprot Product Information
Uniprot Description
MKK4: dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 11 B3|11 40.53 cM
Cellular Component: axon; cytoplasm; cytosol; dendrite cytoplasm; nucleus; perikaryon
Molecular Function: ATP binding; JUN kinase kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; receptor signaling protein serine/threonine kinase activity
Biological Process: activation of JNK activity; JNK cascade; MAPKKK cascade; positive regulation of apoptosis; positive regulation of DNA replication; positive regulation of neuron apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; response to wounding
Research Articles on MKK4 / MEK4 / MAP2K4
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Product Notes
The MKK4 / MEK4 / MAP2K4 map2k4 (Catalog #AAA2546869) is a Recombinant Protein produced from Baculovirus-Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant mouse MAP2K4/GST chimera consists of 633 amino acids and has a calculated molecular mass of 72 kDa. The recombinant protein migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the MKK4 / MEK4 / MAP2K4 map2k4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MKK4 / MEK4 / MAP2K4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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