Mouse mannosidase, alpha, class 2B, member 1 ELISA Kit | MAN2B1 elisa kit
Mouse Lysosomal alpha-mannosidase, MAN2B1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
MAN2B1: Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages. Defects in MAN2B1 are the cause of lysosomal alpha- mannosidosis (AM). AM is a lysosomal storage disease characterized by accumulation of unbranched oligosaccharide chains. This accumulation is expressed histologically as cytoplasmic vacuolation predominantly in the CNS and parenchymatous organs. Depending on the clinical findings at the age of onset, a severe infantile (type I) and a mild juvenile (type II) form of alpha-mannosidosis are recognized. There is considerable variation in the clinical expression with mental retardation, recurrent infections, impaired hearing and Hurler- like skeletal changes being the most consistent abnormalities. Belongs to the glycosyl hydrolase 38 family.
Protein type: Hydrolase; Glycan Metabolism - other glycan degradation; EC 3.2.1.24
Cellular Component: lysosome
Molecular Function: mannose binding; zinc ion binding; hydrolase activity; mannosyl-oligosaccharide mannosidase activity; metal ion binding; hydrolase activity, acting on glycosyl bonds; glucosidase activity; trehalase activity; alpha-mannosidase activity; hydrolase activity, hydrolyzing O-glycosyl compounds; fucosidase activity; hexosaminidase activity; lytic transglycosylase activity; galactosidase activity; amylase activity; carbohydrate binding; mannosidase activity; catalytic activity
Biological Process: mannose metabolic process; learning and/or memory; metabolic process; carbohydrate metabolic process; protein modification process
Research Articles on MAN2B1
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Product Notes
The Mouse MAN2B1 man2b1 (Catalog #AAA9327131) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327131 ELISA Kit recognizes Mouse MAN2B1. It is sometimes possible for the material contained within the vial of "mannosidase, alpha, class 2B, member 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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