Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) Active Protein | LAMP1 active protein

Recombinant Human Lysosome-Associated Membrane Glycoprotein 1 (LAMP1), Partial

Cat. Num. AAA7115106

• Gene Names: LAMP1; LAMPA; CD107a; LGP120
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Lysosome-Associated Membrane Glycoprotein 1 (LAMP1); Recombinant Human Lysosome-Associated Membrane Glycoprotein 1 (LAMP1); Partial; Lysosome-Associated Membrane Glycoprotein 1; LAMP-1; Lysosome-Associated Membrane Protein 1; CD107 Antigen-Like Family Member A; CD107a; LAMP1; LAMP1 active protein

• Host: Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum Filtered 20 mM PB, 150 mM NaCl, pH 7.4
• Sequence Positions: 29-382aa; Partial
• Sequence: AMFMVKNGNGTACIMANFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSM
• Sequence Length: 417

• Species: Human
• Tag: C-terminal FC-tagged
• Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
• Biological Activity: The ED50 as determined by its ability to bind Human Galectin-3 in functional ELISA is less than 20 ng/ml.
• Subcellular Location: Cell Membrane, Single-Pass Type I Membrane Protein, Endosome Membrane, Single-Pass Type I Membrane Protein, Lysosome Membrane, Single-Pass Type I Membrane Protein, Late Endosome
• Protein Families: LAMP Family
• Classification: Drug Target
• Subdivision: CD Antigen
• Pathway: Autophagy-animal
• Preparation and Storage: Store at -20 degree C. For extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for LAMP1 active protein

Relevance: Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells. It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal storage disorders and degranulation on lymphocytes such as CD8+ and NK cells. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells(PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

Function: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Product Categories/Family for LAMP1 active protein

Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 112380628
• NCBI GeneID: 3916
• NCBI Accession #: NP_005552.3
• NCBI GenBank Nucleotide #: NM_005561.4
• UniProt Accession #: P11279
• Molecular Weight: 65.5 kDa
• NCBI Official Full Name: lysosome-associated membrane glycoprotein 1
• NCBI Official Synonym Full Names: lysosomal associated membrane protein 1
• NCBI Official Symbol: LAMP1
• NCBI Official Synonym Symbols: LAMPA; CD107a; LGP120
• NCBI Protein Information: lysosome-associated membrane glycoprotein 1
• UniProt Protein Name: Lysosome-associated membrane glycoprotein 1
• Protein Family: Lysosome-associated membrane glycoprotein
• UniProt Gene Name: LAMP1
• UniProt Synonym Gene Names: LAMP-1
• UniProt Entry Name: LAMP1_HUMAN

NCBI Description

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

Uniprot Description

LAMP1: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Belongs to the LAMP family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: integral to plasma membrane; lysosome; dendrite; multivesicular body; membrane; cell soma; late endosome; cytoplasm; melanosome; plasma membrane; endosome membrane; sarcolemma; external side of plasma membrane

Molecular Function: protein domain specific binding; protein binding; enzyme binding

Biological Process: positive regulation of natural killer cell degranulation; induction of apoptosis by granzyme; protein stabilization; viral reproduction; autophagic cell death; autophagy; positive regulation of natural killer cell mediated cytotoxicity