Interleukin-13 Receptor Subunit alpha-1 (IL13RA1) Active Protein | IL13RA1 active protein

Recombinant Human Interleukin-13 Receptor Subunit alpha-1 (IL13RA1), Partial

Cat. Num. AAA7115054

• Gene Names: IL13RA1; NR4; CT19; CD213A1; IL-13Ra
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Interleukin-13 Receptor Subunit alpha-1 (IL13RA1); Recombinant Human Interleukin-13 Receptor Subunit alpha-1 (IL13RA1); Partial; Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/testis antigen 19; CT19; CD213a1; IL13RA1; IL13R; IL13RA; IL13RA1 active protein

• Host: Mammalian Cell
• Specificity: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum Filtered 1xPBS, pH 7.4
• Sequence Positions: 22-343aa; Extracellular Domain
• Sequence: GGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNST
• Sequence Length: 427

• Species: Human
• Tag: C-terminal 6xHis-tagged
• Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
• Biological Activity: The ED50 as determined by its ability to inhibit IL-13-dependent proliferation of TF-1 human erythroleukemic cells is less than 30 ng/ml.
• Subcellular Location: Membrane, Single-Pass Type I Membrane Protein
• Protein Families: Type I Cytokine Receptor Family, Type 5 Subfamily
• Classification: Cytokine
• Subdivision: Interleukin
• Pathway: Jak-STAT Signaling Pathway
• Preparation and Storage: Store at -20 degree C. For extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for IL13RA1 active protein

Relevance: Interleukin-13 receptor subunit alpha-1(IL13RA1) is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. The human IL13-Ralpha1 was originally cloned based on sequence homology to the mouse IL13-Ralpha1, it share 76% aa sequence identity. Human The IL13-Ralpha1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. The extracellular domain of IL13-Ralpha1 is also closely related to that of IL13-Ralpha2. It binds with low affinity to interleukin-13(IL13). IL13RA1 serves as a primary IL13- binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

Function: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Product Categories/Family for IL13RA1 active protein

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 4504647
• NCBI GeneID: 3597
• NCBI Accession #: NP_001551.1
• NCBI GenBank Nucleotide #: NM_001560.3
• UniProt Accession #: P78552
• Molecular Weight: 37.7 kDa
• NCBI Official Full Name: interleukin-13 receptor subunit alpha-1
• NCBI Official Synonym Full Names: interleukin 13 receptor subunit alpha 1
• NCBI Official Symbol: IL13RA1
• NCBI Official Synonym Symbols: NR4; CT19; CD213A1; IL-13Ra
• NCBI Protein Information: interleukin-13 receptor subunit alpha-1
• UniProt Protein Name: Interleukin-13 receptor subunit alpha-1
• Protein Family: Interleukin-13 receptor
• UniProt Gene Name: IL13RA1
• UniProt Synonym Gene Names: IL13R; IL13RA; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; CT19
• UniProt Entry Name: I13R1_HUMAN

NCBI Description

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

Uniprot Description

IL13R: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Belongs to the type I cytokine receptor family. Type 5 subfamily.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: interleukin-13 receptor complex; plasma membrane

Molecular Function: protein binding; interleukin-13 receptor activity

Biological Process: positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; positive regulation of B cell proliferation