Human mastermind-like 2 (Drosophila) ELISA Kit | MAML2 elisa kit
Human Mastermind-like protein 2, MAML2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Uniprot Description
MAML2: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa. Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. Belongs to the mastermind family.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: nucleoplasm; Golgi apparatus; nuclear speck; nucleus
Molecular Function: transcription coactivator activity
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression
Research Articles on MAML2
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Product Notes
The Human MAML2 maml2 (Catalog #AAA9342671) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342671 ELISA Kit recognizes Human MAML2. It is sometimes possible for the material contained within the vial of "mastermind-like 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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