MAGE 1 Recombinant Protein | MAGEA1 recombinant protein

MAGE 1, Recombinant, Human (Antigen MZ2-E, MAGE1A, MAGEA1, Melanoma Antigen 1, Melanoma Associated Antigen MZ2-E, MGC9326)

Cat. Num. AAA638236

• Gene Names: MAGEA1; CT1.1; MAGE1
• Purity: Purified; Purified by standard chromatographic techniques.
• Synonyms: MAGE 1; Recombinant; Human (Antigen MZ2-E; MAGE1A; MAGEA1; Melanoma Antigen 1; Melanoma Associated Antigen MZ2-E; MGC9326); MAGEA1 recombinant protein

• Host: E Coli
• Purity/Purification: Purified; Purified by standard chromatographic techniques.
• Form/Format: Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA and 20% glycerol.

• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Structure

(Precursor- Protein structure and amino acid sequence:)

Related Product Information for MAGEA1 recombinant protein

Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on mormal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Recombinant Human MAGE1 produced in E. coli is a disulfide-linked monomeric, non-glycosylated, polypeptide chain containing 200aa and having a molecular mass of 22.7kD.

Product Categories/Family for MAGEA1 recombinant protein

Molecular Biology; MB-Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 416115
• NCBI GeneID: 4100
• UniProt Accession #: P43355; O00346; B2RC81; AAB33086
• Molecular Weight: 22.7kD
• NCBI Official Full Name: MAGE-1
• NCBI Official Synonym Full Names: melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
• NCBI Official Symbol: MAGEA1
• NCBI Official Synonym Symbols: CT1.1; MAGE1
• NCBI Protein Information: melanoma-associated antigen 1; antigen MZ2-E; MAGE-1 antigen; melanoma antigen MAGE-1; cancer/testis antigen 1.1; melanoma antigen family A 1; melanoma-associated antigen MZ2-E; cancer/testis antigen family 1, member 1
• UniProt Protein Name: Melanoma-associated antigen 1
• Protein Family: Melanoma-associated antigen
• UniProt Gene Name: MAGEA1
• UniProt Synonym Gene Names: MAGE1; MAGE1A; CT1.1
• UniProt Entry Name: MAGA1_HUMAN

NCBI Description

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

Uniprot Description

MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; histone deacetylase binding

Biological Process: transcription, DNA-dependent; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter