Human MACRO domain containing 1 ELISA Kit | MACROD1 elisa kit
Human MACRO domain-containing protein 1, MACROD1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
MACROD1: Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein.
Protein type: Mitochondrial; EC 3.5.1.-
Chromosomal Location of Human Ortholog: 11q11
Cellular Component: mitochondrion; nucleus
Molecular Function: deacetylase activity; protein binding; hydrolase activity, acting on glycosyl bonds
Biological Process: protein amino acid de-ADP-ribosylation; purine nucleoside metabolic process; response to DNA damage stimulus
Research Articles on MACROD1
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Product Notes
The Human MACROD1 macrod1 (Catalog #AAA9338143) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338143 ELISA Kit recognizes Human MACROD1. It is sometimes possible for the material contained within the vial of "MACRO domain containing 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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