Cadherin-16 Blocking Peptide | M810 blocking peptide

Cadherin-16 (M810) Peptide

Cat. Num. AAA3002315

• Applications: Blocking
• Purity: Synthetic peptide Cadherin-16 (M810). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Cadherin-16; Cadherin-16 (M810) Peptide; Cadherin 16; Kidney-specific cadherin; Ksp-cadherin; CDH16; UNQ695/PRO1340; CDH 16; M810 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002314 Cadherin-16 (M810) pAb.
• Purity/Purification: Synthetic peptide Cadherin-16 (M810). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 807

• Applicable Applications for M810 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for M810 blocking peptide

The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. Cadherin-16, also known as Ksp-Cadherin, is a type I membrane protein which is kidney-specific. Cadherin-16 is expressed exclusively in the basolateral membrane of renal tubular epithelial cells. The human Ksp-cadherin gene (Cadherin-16) maps to chromosome 16q21-proximal 16q22. The mouse Ksp-cadherin gene was localized to a highly syntenic region of distal Chromosome 8

NCBI and Uniprot Product Information

• NCBI GI #: 325296969
• NCBI GeneID: 1014
• NCBI Accession #: NP_001191673.1
• NCBI GenBank Nucleotide #: NP_001191673.1
• UniProt Accession #: O75309
• NCBI Official Full Name: cadherin-16 isoform 2
• NCBI Official Synonym Full Names: cadherin 16
• NCBI Official Symbol: CDH16
• NCBI Protein Information: cadherin-16
• UniProt Protein Name: Cadherin-16
• Protein Family: Cadherin
• UniProt Gene Name: CDH16
• UniProt Synonym Gene Names: Ksp-cadherin
• UniProt Entry Name: CAD16_HUMAN

NCBI Description

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Uniprot Description

CDH16: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: basolateral plasma membrane; integral to membrane

Molecular Function: calcium ion binding

Biological Process: calcium-dependent cell-cell adhesion; cell adhesion; homophilic cell adhesion