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MD-2 Blocking Peptide | LY96 blocking peptide

MD-2 Peptide

Gene Names
LY96; MD2; MD-2; ly-96; ESOP-1
Applications
Blocking (BL)
Synonyms
MD-2; MD-2 Peptide; MD2; ly-96; ESOP-1; ESOP1; Lymphocyte antigen 96; Ly-96; lymphocyte antigen 96; LY96 blocking peptide
Ordering
For Research Use Only!
Form/Format
Liquid
Concentration
200 ug/mL (varies by lot)
Sequence Length
160
Applicable Applications for LY96 blocking peptide
Blocking (BL)
Application Notes
MD-2 peptide is used for blocking the activity of MD-2 antibody.
Species
Human
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
13 amino acids near the middle region of human MD-2.
Preparation and Storage
Store MD-2 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
14,933 Da
NCBI Official Full Name
lymphocyte antigen 96
NCBI Official Synonym Full Names
lymphocyte antigen 96
NCBI Official Symbol
LY96
NCBI Official Synonym Symbols
MD2; MD-2; ly-96; ESOP-1
NCBI Protein Information
lymphocyte antigen 96; protein MD-2; myeloid differentiation protein-2
UniProt Protein Name
Lymphocyte antigen 96
UniProt Gene Name
LY96
UniProt Synonym Gene Names
ESOP1; MD2; Ly-96
UniProt Entry Name
LY96_HUMAN

NCBI Description

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

Uniprot Description

LY96: a secreted protein that binds to the extracellular domains of TLR2 and TLR4. Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor complex, a multi-protein complex containing at least CD14, LY96 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: extracellular space; plasma membrane; lipopolysaccharide receptor complex; endosome membrane

Molecular Function: protein binding; coreceptor activity; lipopolysaccharide receptor activity

Biological Process: MyD88-dependent toll-like receptor signaling pathway; I-kappaB kinase/NF-kappaB cascade; cell surface receptor linked signal transduction; detection of lipopolysaccharide; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; positive regulation of lipopolysaccharide-mediated signaling pathway; cellular defense response; innate immune response; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway

Research Articles on LY96

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Product Notes

The LY96 ly96 (Catalog #AAA152717) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's MD-2 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). MD-2 peptide is used for blocking the activity of MD-2 antibody. Researchers should empirically determine the suitability of the LY96 ly96 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MD-2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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