Rat Leukotriene C4 synthase ELISA Kit | LTC4S elisa kit
Rat Leukotriene C4 synthase (LTC4S) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Uniprot Description
LTC4S: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency). LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. Belongs to the MAPEG family.
Protein type: Membrane protein, integral; Lipid Metabolism - arachidonic acid; Nuclear envelope; EC 4.4.1.20; Lyase; Membrane protein, multi-pass; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle; nuclear envelope; nuclear outer membrane
Molecular Function: enzyme activator activity; glutathione binding; glutathione peroxidase activity; glutathione transferase activity; leukotriene-C4 synthase activity; lipid binding; protein binding; protein heterodimerization activity
Biological Process: arachidonic acid metabolic process; leukotriene biosynthetic process; leukotriene metabolic process; lipoxygenase pathway; positive regulation of catalytic activity; response to axon injury; response to drug; response to inorganic substance
Disease: Leukotriene C4 Synthase Deficiency
Research Articles on LTC4S
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Product Notes
The Rat LTC4S ltc4s (Catalog #AAA2607694) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2607694 ELISA Kit recognizes Rat LTC4S. It is sometimes possible for the material contained within the vial of "Leukotriene C4 synthase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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