Human lanosterol synthase (2, 3-oxidosqualene-lanosterol cyclase) ELISA Kit | LSS elisa kit

Human Lanosterol synthase, LSS ELISA Kit

Cat. Num. AAA9327168

• Gene Names: LSS; OSC
• Reactivity: Human
• Synonyms: lanosterol synthase (2; 3-oxidosqualene-lanosterol cyclase); Human Lanosterol synthase; LSS ELISA Kit; Human Lanosterol synthase (LSS) ELISA kit; FLJ25486; FLJ35015; FLJ39450; FLJ46393; OSC; 2; 3-epoxysqualene-lanosterol cyclase; lanosterol synthase; LSS elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Body fluids, tissue homogenates, secretions or feces samples
• Assay Type: Quantitative Sandwich
• Detection Range: 0.25 ng/ml - 8 ng/ml
• Sensitivity: 0.1 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for LSS elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of LSS (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 47933397
• NCBI GeneID: 4047
• NCBI Accession #: NP_001001438.1
• NCBI GenBank Nucleotide #: NM_001001438.2
• UniProt Accession #: P48449; Q8IYL6; Q9UEZ1; B4DJZ9; D3DSN0; E9PEI9; G5E9Q9
• Molecular Weight: 83,309 Da
• NCBI Official Full Name: lanosterol synthase isoform 1
• NCBI Official Synonym Full Names: lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
• NCBI Official Symbol: LSS
• NCBI Official Synonym Symbols: OSC
• NCBI Protein Information: lanosterol synthase; hOSC; oxidosqualene--lanosterol cyclase; 2,3-epoxysqualene-lanosterol cyclase; 2,3-epoxysqualene--lanosterol cyclase
• UniProt Protein Name: Lanosterol synthase
• Protein Family: Lysostaphin
• UniProt Gene Name: LSS
• UniProt Synonym Gene Names: OSC; OSC; hOSC
• UniProt Entry Name: ERG7_HUMAN

NCBI Description

The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]

Uniprot Description

LSS: Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Belongs to the terpene cyclase/mutase family.

Protein type: Lipid Metabolism - steroid biosynthesis; EC 5.4.99.7; Isomerase

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: endoplasmic reticulum membrane; membrane; lipid particle

Molecular Function: lanosterol synthase activity

Biological Process: steroid metabolic process; cholesterol biosynthetic process

Disease: Cataract 44