LSM4 Homolog Recombinant Protein | LSM4 recombinant protein
Recombinant Human LSM4 Homolog, U6 Small Nuclear RNA Associated
Gene Names
LSM4; GRP; YER112W
Purity
Greater than 90.0% as determined by SDS-PAGE.
Synonyms
LSM4 Homolog; Recombinant Human LSM4 Homolog; U6 Small Nuclear RNA Associated; LSM4 Human; U6 Small Nuclear RNA Associated Human Recombinant; U6 snRNA-associated Sm-like protein LSm4; Glycine-rich protein; GRP; LSM4; YER112W; LSM4 recombinant protein
Host
E Coli
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
The LSM4 solution (0.5 mg/ml) 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Sterile Filtered colorless solution.
Sterile Filtered colorless solution.
Sequence
MGSSHHHHHH SSGLVPRGSH MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG DKFWRMPECY IRGSTIKYLR IPDEIIDMVK EEVVAKGRGR GGLQQQKQQK GRGMGGAGRG VFGGRGRGGI PGTGRGQPEK KPGRQAGKQ
Sequence Length
139
Preparation and Storage
LSM4 should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Related Product Information for LSM4 recombinant protein
Description: LSM4 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 159 amino acids (1-139 a.a.) and having a molecular mass of 17.5kDa. The LSM4 is purified by proprietary chromatographic techniques.
Introduction: LSM4 (U6 snRNA-associated Sm-like protein) forms donut-shaped heptameric complexes which are involved in various steps of RNA metabolism. LSM4 facilitates RNA protein interactions and structural changes which are essential during ribosomal subunit assembly. LSM4 binds specifically to the 3'-terminal U-tract of U6 snRNA.
Introduction: LSM4 (U6 snRNA-associated Sm-like protein) forms donut-shaped heptameric complexes which are involved in various steps of RNA metabolism. LSM4 facilitates RNA protein interactions and structural changes which are essential during ribosomal subunit assembly. LSM4 binds specifically to the 3'-terminal U-tract of U6 snRNA.
Product Categories/Family for LSM4 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
15,350 Da
NCBI Official Full Name
U6 snRNA-associated Sm-like protein LSm4 isoform 1
NCBI Official Synonym Full Names
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NCBI Official Symbol
LSM4
NCBI Official Synonym Symbols
GRP; YER112W
NCBI Protein Information
U6 snRNA-associated Sm-like protein LSm4; glycine-rich protein
UniProt Protein Name
U6 snRNA-associated Sm-like protein LSm4
Protein Family
UniProt Gene Name
LSM4
UniProt Synonym Gene Names
GRP
UniProt Entry Name
LSM4_HUMAN
NCBI Description
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
LSM4: Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.
Protein type: RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; cytosol
Molecular Function: protein binding
Biological Process: RNA splicing; gene expression; mRNA processing; mRNA catabolic process, deadenylation-dependent decay
Research Articles on LSM4
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Product Notes
The LSM4 lsm4 (Catalog #AAA145151) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG DKFWRMPECY IRGSTIKYLR IPDEIIDMVK EEVVAKGRGR GGLQQQKQQK GRGMGGAGRG VFGGRGRGGI PGTGRGQPEK KPGRQAGKQ. It is sometimes possible for the material contained within the vial of "LSM4 Homolog, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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