Mouse leucine-rich repeats and WD repeat domain containing 1 ELISA Kit | LRWD1 elisa kit
Mouse Leucine-rich repeat and WD repeat-containing protein 1, LRWD1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
LRWD1: Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recongnizes and binds these repressive marks by itself or needs additional factors. Belongs to the LRWD1 family.
Cellular Component: centric heterochromatin; chromosome, telomeric region; cytoskeleton; cytoplasm; chromosome; nuclear origin of replication recognition complex; nucleus; chromosome, pericentric region
Molecular Function: methyl-CpG binding; chromatin binding; methylated histone residue binding
Biological Process: establishment and/or maintenance of chromatin architecture; chromatin modification; DNA replication
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Product Notes
The Mouse LRWD1 lrwd1 (Catalog #AAA9334626) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334626 ELISA Kit recognizes Mouse LRWD1. It is sometimes possible for the material contained within the vial of "leucine-rich repeats and WD repeat domain containing 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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