Human leucine-rich repeats and WD repeat domain containing 1 ELISA Kit | LRWD1 elisa kit

Human Leucine-rich repeat and WD repeat-containing protein 1, LRWD1 ELISA Kit

Cat. Num. AAA9316467

• Gene Names: LRWD1; ORCA; CENP-33
• Reactivity: Human
• Synonyms: leucine-rich repeats and WD repeat domain containing 1; Human Leucine-rich repeat and WD repeat-containing protein 1; LRWD1 ELISA Kit; Human Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1) ELISA kit; DKFZp434K1815; ; LRWD1 elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 3.12ng/ml-100ng/ml
• Sensitivity: 1.0ng/ml
• Intra-assay Precision: Intra-assay CV (%)is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for LRWD1 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of LRWD1 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 23097240
• NCBI GeneID: 222229
• NCBI Accession #: NP_690852.1
• NCBI GenBank Nucleotide #: NM_152892.1
• UniProt Accession #: Q9UFC0; Q8N0T9; Q8WV43; Q96GJ2; A8K4K2; B2R9G2
• Molecular Weight: 70,861 Da
• NCBI Official Full Name: leucine-rich repeat and WD repeat-containing protein 1
• NCBI Official Synonym Full Names: leucine-rich repeats and WD repeat domain containing 1
• NCBI Official Symbol: LRWD1
• NCBI Official Synonym Symbols: ORCA; CENP-33
• NCBI Protein Information: leucine-rich repeat and WD repeat-containing protein 1; centromere protein 33; ORC-associated protein; origin recognition complex associated; origin recognition complex-associated protein
• UniProt Protein Name: Leucine-rich repeat and WD repeat-containing protein 1
• Protein Family: Leucine-rich repeat and WD repeat-containing protein
• UniProt Gene Name: LRWD1
• UniProt Synonym Gene Names: CENP33; ORCA; CENP-33; ORC-associated protein; ORCA
• UniProt Entry Name: LRWD1_HUMAN

Uniprot Description

LRWD1: Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recongnizes and binds these repressive marks by itself or needs additional factors. Belongs to the LRWD1 family.

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: centric heterochromatin; cytoplasm; microtubule organizing center; nuclear origin of replication recognition complex; nucleus

Molecular Function: protein binding; methyl-CpG binding; chromatin binding; methylated histone residue binding

Biological Process: establishment and/or maintenance of chromatin architecture; DNA replication initiation; chromatin modification