Human leucine-rich repeat kinase 1 ELISA Kit | LRRK1 elisa kit
Human Leucine-rich repeat serine/threonine-protein kinase 1, LRRK1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
LRRK1: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). Involved in the trafficking of epidermal growth factor (EGFR) from early to late endosomes. Forms a complex with activated EGFR via the adaptor protein Grb2. Subsequently, LRRK1 and EGFR are internalized and co-localized in early endosomes. LRRK1 is phosphorylated by EGFR, inhibiting its kinase activity. The reduction of kinase activity plays an important role in endosomal trafficking of the EGFR. Serves as a scaffold expediting the interaction of EGFR with the endosomal sorting complex required for efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Plays a critical role in negative regulation of bone mass in part through modulating the c-Src signaling pathway in mice. Phosphorylation of c-Src at Tyr-527 is significantly elevated whereas at Tyr-416 is decreased in LRRK1 KO mouse osteoclasts.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; LRRK family
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: mitochondrion; cytoplasm
Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; GTP binding; metal ion binding; ATP binding
Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; small GTPase mediated signal transduction; protein amino acid phosphorylation; bone resorption
Research Articles on LRRK1
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Product Notes
The Human LRRK1 lrrk1 (Catalog #AAA9319845) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319845 ELISA Kit recognizes Human LRRK1. It is sometimes possible for the material contained within the vial of "leucine-rich repeat kinase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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