LRRFIP1 recombinant protein

Recombinant Human LRRFIP1 protein

Cat. Num. AAA1561483

• Gene Names: LRRFIP1; GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1
• Purity: >90% as determined by SDS-PAGE
• Synonyms: LRRFIP1; Recombinant Human LRRFIP1 protein; Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; GC-binding factor 2; TAR RNA-interacting protein; LRRFIP1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human LRRFIP1 (Asp615-Ser735) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for LRRFIP1 recombinant protein

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Product Categories/Family for LRRFIP1 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 212276096
• NCBI GeneID: 9208
• NCBI Accession #: NP_001131022
• NCBI GenBank Nucleotide #: NM_001137552.1
• UniProt Accession #: Q32MZ4; O75766; O75799; Q32MZ5; Q53T49; Q6PKG2; Q9Y607; E9PGZ2
• Molecular Weight: 73,060 Da
• NCBI Official Full Name: leucine-rich repeat flightless-interacting protein 1 isoform 3
• NCBI Official Synonym Full Names: leucine rich repeat (in FLII) interacting protein 1
• NCBI Official Symbol: LRRFIP1
• NCBI Official Synonym Symbols: GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1
• NCBI Protein Information: leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; NEDD8-conjugating enzyme; TAR RNA-interacting protein; LRR FLII-interacting protein 1
• UniProt Protein Name: Leucine-rich repeat flightless-interacting protein 1
• Protein Family: Leucine-rich repeat flightless-interacting protein
• UniProt Gene Name: LRRFIP1
• UniProt Synonym Gene Names: GCF2; TRIP; LRR FLII-interacting protein 1
• UniProt Entry Name: LRRF1_HUMAN

Uniprot Description

LRRFIP1: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cytoskeleton; cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; double-stranded RNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of interferon type I production; innate immune response; negative regulation of transcription, DNA-dependent