Low-density lipoprotein receptor-related protein 5 (LRP5) Recombinant Protein | LRP5 recombinant protein

Recombinant Human Low-density lipoprotein receptor-related protein 5 (LRP5) , partial

• Gene Names: LRP5; HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; PCLD4; VBCH2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Low-density lipoprotein receptor-related protein 5 (LRP5); Recombinant Human Low-density lipoprotein receptor-related protein 5 (LRP5); partial; LRP5 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,615

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for LRP5 recombinant protein

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

NCBI and Uniprot Product Information

• NCBI GI #: 631790829
• NCBI GeneID: 4041
• NCBI Accession #: NP_001278831.1
• NCBI GenBank Nucleotide #: NM_001291902.1
• UniProt Accession #: O75197; Q96TD6; Q9UES7; Q9UP66
• Molecular Weight: 179,145 Da
• NCBI Official Full Name: low-density lipoprotein receptor-related protein 5 isoform 2
• NCBI Official Synonym Full Names: LDL receptor related protein 5
• NCBI Official Symbol: LRP5
• NCBI Official Synonym Symbols: HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; PCLD4; VBCH2
• NCBI Protein Information: low-density lipoprotein receptor-related protein 5
• UniProt Protein Name: Low-density lipoprotein receptor-related protein 5
• Protein Family: Low-density lipoprotein receptor-related protein
• UniProt Gene Name: LRP5
• UniProt Synonym Gene Names: LR3; LRP7; LRP-5

NCBI Description

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Description

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (). Required for posterior patterning of the epiblast during gastrulation ().