Alpha-like toxin Lqh3 Recombinant Protein | LqhIII recombinant protein
Recombinant Leiurus quinquestriatus hebraeus Alpha-like toxin Lqh3
NCBI and Uniprot Product Information
Uniprot Description
Binds voltage-independently at site-3 of sodium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This alpha-like toxin is highly toxic to insects and competes with LqhaIT on binding to insect sodium channels. Differs from classical anti-mammalian alpha-toxins as it inhibits sodium channel inactivation in cell bodies of hippocampus brain neurons, on which the anti-mammalian Lqh2 is inactive, and is unable to affect Nav1.2 in the rat brain, on which Lqh2 is highly active. Moreover, its pharmacological properties are unique in that its binding affinity for insect channels drops >30-fold at pH 8.5 versus pH 6.5, and its rate of association with receptor site-3 on both insect and mammalian sodium channels is 4-15-fold slower compared with LqhaIT and Lqh2.
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Product Notes
The Alpha-like toxin Lqh3 lqhiii (Catalog #AAA1241379) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-67, Full length protein. The amino acid sequence is listed below: VRDGYIAQPE NCVYHCFPGS SGCDTLCKEK GGTSGHCGFK VGHGLACWCN ALPDNVGIIV EGEKCHS. It is sometimes possible for the material contained within the vial of "Alpha-like toxin Lqh3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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