LOXL3 / Lysyl Oxidase Homolog 3 Recombinant Protein | LOXL3 recombinant protein

Human LOXL3 / Lysyl Oxidase Homolog 3 Recombinant Protein

• Gene Names: LOXL3; LOXL
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: LOXL3 / Lysyl Oxidase Homolog 3; Human LOXL3 / Lysyl Oxidase Homolog 3 Recombinant Protein; Lysyl oxidase homolog 3; Lysyl oxidase-like protein 3; LOXL; LOXL3 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 608

• Applicable Applications for LOXL3 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Interacts with STAT3 (PubMed:28065600).
• Entry Function: Isoform 2: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530).
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 574957232
• NCBI GeneID: 84695
• NCBI Accession #: NP_001276093.1
• NCBI GenBank Nucleotide #: NP_001276093.1
• UniProt Accession #: P58215
• NCBI Official Full Name: lysyl oxidase homolog 3 isoform 2
• NCBI Official Synonym Full Names: lysyl oxidase like 3
• NCBI Official Symbol: LOXL3
• NCBI Official Synonym Symbols: LOXL
• NCBI Protein Information: lysyl oxidase homolog 3
• UniProt Protein Name: Lysyl oxidase homolog 3
• Protein Family: Lysyl oxidase
• UniProt Gene Name: LOXL3
• UniProt Synonym Gene Names: LOXL
• UniProt Entry Name: LOXL3_HUMAN

NCBI Description

This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016]

Uniprot Description

LOXL3: a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Protein type: Oxidoreductase; EC 1.4.3.-; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: cytoplasm; extracellular region; extracellular space; membrane; nucleus

Molecular Function: copper ion binding; protein binding; protein-lysine 6-oxidase activity; scavenger receptor activity

Biological Process: epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent; receptor-mediated endocytosis