Regulator of G-protein signaling loco (loco) Recombinant Protein | loco recombinant protein

Recombinant Drosophila melanogaster Regulator of G-protein signaling loco (loco), partial

• Gene Names: loco; CG17229; CG5248; dLoco; DmelCG5248; Loco; LOCO
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Regulator of G-protein signaling loco (loco); Recombinant Drosophila melanogaster Regulator of G-protein signaling loco (loco); partial; loco recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 872

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 24649087
• NCBI GeneID: 42672
• NCBI Accession #: NP_732773.1
• NCBI GenBank Nucleotide #: NM_170030.2
• UniProt Accession #: Q9VCX1; Q9NGQ0; Q9UB06; Q9XYX8
• Molecular Weight: 96,117 Da
• NCBI Official Full Name: locomotion defects, isoform D
• NCBI Official Synonym Full Names: locomotion defects
• NCBI Official Symbol: loco
• NCBI Official Synonym Symbols: CG17229; CG5248; dLoco; DmelCG5248; Loco; LOCO
• NCBI Protein Information: CG5248 gene product from transcript CG5248-RD
• UniProt Protein Name: Regulator of G-protein signaling loco
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: loco
• UniProt Synonym Gene Names: RGS; Loco

Uniprot Description

Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI and GAP activities on G(i) alpha subunit Galphai. Confers GAP activity on G(o) alpha subunit Galphao and G(i) alpha subunit Galphai. Involved in the dorsal-ventral axis formation of the egg. Acts as a G-protein signaling for glial cell differentiation during embryogenesis; Galphai, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord. May be essential for nurse cell dumping during oogenesis. Required in neuroblast asymmetrical cell division. Plays a role in stress resistance and life span control.