Mouse LMBR1 domain containing 1 ELISA Kit | LMBRD1 elisa kit
Mouse Probable lysosomal cobalamin transporter, LMBRD1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
LMBRD1: Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV). Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAHCF). A disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12. Belongs to the LIMR family. LMBRD1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: membrane; lysosome; plasma membrane; integral to membrane; clathrin-coated endocytic vesicle
Molecular Function: cobalamin binding; insulin receptor binding
Biological Process: negative regulation of glucose import; negative regulation of protein kinase B signaling cascade; transport; regulation of MAPKKK cascade; negative regulation of insulin receptor signaling pathway
Research Articles on LMBRD1
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Product Notes
The Mouse LMBRD1 lmbrd1 (Catalog #AAA9318322) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318322 ELISA Kit recognizes Mouse LMBRD1. It is sometimes possible for the material contained within the vial of "LMBR1 domain containing 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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