Human lin-9 homolog (C. elegans) ELISA Kit | LIN9 elisa kit
Human Protein lin-9 homolog, LIN9 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Description
LIN9: a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. Component of the DREAM complex composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBBP4, RBL2, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1. Three alternative spliced human isoforms have been reported.
Protein type: Transcription, coactivator/corepressor; Tumor suppressor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 1q42.12
Cellular Component: nucleoplasm; transcriptional repressor complex
Molecular Function: protein binding
Biological Process: transcription, DNA-dependent; regulation of cell cycle; mitotic cell cycle; G2/M transition of mitotic cell cycle
Research Articles on LIN9
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Product Notes
The Human LIN9 lin9 (Catalog #AAA9336956) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336956 ELISA Kit recognizes Human LIN9. It is sometimes possible for the material contained within the vial of "lin-9 homolog (C. elegans), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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