Human LIM domains containing 1 ELISA Kit | LIMD1 elisa kit

Human LIM domain-containing protein 1, LIMD1 ELISA Kit

Cat. Num. AAA9333468

• Reactivity: Human
• Synonyms: LIM domains containing 1; Human LIM domain-containing protein 1; LIMD1 ELISA Kit; Human LIM domain-containing protein 1 (LIMD1) ELISA kit; LIMD1 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Body fluids, tissue homogenates, secretions or feces samples
• Assay Type: Quantitative Sandwich
• Detection Range: 6.25 ng/ml - 200 ng/ml
• Sensitivity: 1.0 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for LIMD1 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of LIMD1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 7657307
• NCBI GeneID: 8994
• NCBI Accession #: NP_055055.1
• NCBI GenBank Nucleotide #: NM_014240.2
• UniProt Accession #: Q9UGP4; Q17RQ1; Q9BQQ9; Q9NQ47
• Molecular Weight: 72,190 Da
• NCBI Official Full Name: LIM domain-containing protein 1
• NCBI Official Synonym Full Names: LIM domains containing 1
• NCBI Official Symbol: LIMD1
• NCBI Protein Information: LIM domain-containing protein 1
• UniProt Protein Name: LIM domain-containing protein 1
• Protein Family: LIM domain-containing protein
• UniProt Gene Name: LIMD1
• UniProt Entry Name: LIMD1_HUMAN

Uniprot Description

LIMD1: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. Belongs to the zyxin/ajuba family.

Protein type: Tumor suppressor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: focal adhesion; adherens junction; cytoplasm; nucleus

Molecular Function: protein binding; zinc ion binding; transcription corepressor activity

Biological Process: cell migration; transcription, DNA-dependent; multicellular organismal development; cytoskeleton organization and biogenesis; miRNA-mediated gene silencing; signal transduction; osteoblast development; regulation of cell shape; regulation of transcription, DNA-dependent; response to hypoxia; negative regulation of osteoblast differentiation; cytoplasmic mRNA processing body assembly; negative regulation of transcription, DNA-dependent; phosphorylation