LILRA2 recombinant protein

LILRA2 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8122137

• Gene Names: LILRA2; ILT1; LIR7; CD85H; LIR-7
• Purity: >95% as determined by SDS-PAGE
• Synonyms: LILRA2; LILRA2 Protein; Human; Recombinant (hFc Tag); Human LILRA2 Protein (Fc Tag); CD85H Protein; ILT1 Protein; LIR-7 Protein; LIR7 Protein; leukocyte immunoglobulin-like receptor; subfamily A (with TM domain); member 2; LILRA2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asn449

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gly 24
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human LILRA2 (NP_001124389.2)(Met1-Asn449) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for LILRA2 recombinant protein

Background: LILRA2 (Leukocyte Immunoglobulin Like Receptor A2, also known as LIR7 and ILT1) is a Protein Coding gene. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses the innate immune response. It is an activating receptor highly expressed in inflammatory tissues and is involved in granulocyte and macrophage activation. LILRA2 is primarily expressed on the surface of cells of the innate immunity including monocytes, macrophages, neutrophils, basophils, and eosinophils but not on lymphocytes and NK cells. LILRA2 cross-linking on monocytes induces pro-inflammatory cytokines while inhibiting dendritic cell differentiation and antigen presentation. Diseases associated with LILRA2 include Tuberculoid Leprosy and Leprosy 3.

NCBI and Uniprot Product Information

• NCBI GI #: 590122028
• NCBI GeneID: 11027
• NCBI Accession #: NP_001124389.2
• NCBI GenBank Nucleotide #: NM_001130917.2
• Molecular Weight: 48,023 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily A member 2 isoform a
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor A2
• NCBI Official Symbol: LILRA2
• NCBI Official Synonym Symbols: ILT1; LIR7; CD85H; LIR-7
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily A member 2
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily

NCBI Description

This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]