Leukemia Inhibitory Factor/LIF Recombinant Protein | LIF recombinant protein

Recombinant Human Leukemia Inhibitory Factor/LIF Protein

Cat. Num. AAA2552903

• Gene Names: LIF; CDF; DIA; HILDA; MLPLI
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Leukemia Inhibitory Factor/LIF; Recombinant Human Leukemia Inhibitory Factor/LIF Protein; Leukemia Inhibitory Factor; LIF; Differentiation-Stimulating Factor; D Factor; Melanoma-Derived LPL Inhibitor; MLPLI; Emfilermin; HILDA; LIF recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, 0.02% Tween 20, pH 7.4.
• Sequence Positions: Ser23-Phe202
• Sequence Length: 88

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for LIF recombinant protein

Leukemia Inhibitory Factor (LIF) is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. Human and murine mature LIF exhibit a 78% sequence identity at the amino acid level. Human LIF is equally active on human and mouse cells. Murine LIF is approximately 1000 fold less active on human cells than human LIF.

NCBI and Uniprot Product Information

• NCBI GI #: 380418324
• NCBI GeneID: 3976
• NCBI Accession #: NP_001244064.1
• NCBI GenBank Nucleotide #: NM_001257135.1
• UniProt Accession #: P15018; Q52LZ2; B2RCW7; B5MC23
• Molecular Weight: Molecular Mass: 19.7 kDa; Actual Protein Molecular Mass: 18 kDa
• NCBI Official Full Name: leukemia inhibitory factor isoform 2
• NCBI Official Synonym Full Names: LIF, interleukin 6 family cytokine
• NCBI Official Symbol: LIF
• NCBI Official Synonym Symbols: CDF; DIA; HILDA; MLPLI
• NCBI Protein Information: leukemia inhibitory factor
• UniProt Protein Name: Leukemia inhibitory factor
• Protein Family: Leukemia inhibitory factor
• UniProt Gene Name: LIF
• UniProt Synonym Gene Names: HILDA; LIF; D factor; MLPLI

NCBI Description

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Uniprot Description

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.